extract of Glycyrrhiza glabra Linn. in aspirin induced ulcer in rats. . The aim of the study was to determine anti ulcer activity of stem bark of. Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total Keywords: Anti-ulcer, Cold-restraint, Glycyrrhiza glabra, GutGardTM. The present research has been carried out to investigate antiulcer activity of ethanolic extract of Cynodon dactylon, Ocimum sanctum, Glycyrrhiza glabra, Ficus.

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Therefore the antiulcer activity of hydroalcoholic extract of G. Synthesis and anti-ulcer activity of new derivatives of glycyrrhetic,oleanolic and ursolic acids. HEGG inhibit formation of ulcers in all four models and at all doses significantly.

Open in a separate window. The experimental data were tested for statistical significance by means of analysis of variance with one-way classification.

The HEGG-induced gastroprotection in higher and lower doses were more effective. This model, cold restraint stress-induced gastric ulcers, has been used due to goycyrrhiza reproducibility and similarity with human gastric ulcers to evaluate the effect of drugs on gastric secretion, stress and gastrointestinal motility. Consequently, the objective of the present study was to validate the antiulcer effect attributed to G.

Two mechanisms have been suggested includeing inhibition of glucocorticoid metabolism and potentiating their effects, and inhibition of classical complement pathway activation.

Ulcer index UI and Preventive Index PI of each of the groups was calculated using standard methods as described above. Oral administration of absolute ethanol produced multiple mucosal lesions in the mice stomach. However, studies are needed to prove the safety of its use, as well as the analysis of acute toxicity is fundamentally important to identify the doses that could be used, and to reveal the possible clinical acitvity caused by the extract.


Swiss mice were randomly divided into six groups, fasted before the glabrra, but had free access to water.

The plant kingdom as a source of antiulcer remedies. The study was conducted on Swiss mice of either sex, weighing 25—30 g. A depletion of stomach wall mucus after oral ethanol administration has also been reported This also implies that the antiulcergenic activity afforded by HEGG may be associated with its antiinflamatory action, antioxidant properties, cytoprotective activity, and also due to increase in the prostaglandin formation.

The constituent s responsible for antiulcer effect of G. Find articles by Ghader Jalilzadeh-Amin.

Anti Ulcer Activity Of Aloevera And Glycyrrhiza Glabra In Swiss Albino Rats |

He is a GPAT qualified student and presented oral and poster presentation in national level seminars. The creation of ethanol-induced gastric lesions is of multifactorial origin with decrease in gastric mucus amount as one of the involved factors. Anti-ulcer properties of saponins have been reported Guidelines Upcoming Special Issues. Pre-treatment with omeprazole and HEGG were found to decrease the ethanol-induced gastric mucosal injuries.

Nassiri M, Hosseinzadeh H. Roles of endogenous prostaglandins and cyclooxygenase isozymes in mucosal defense of inflamed rat stomach.

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Anti-ulcer activity of aqueous and ethanolic extracts of Glycyrrhiza glabra L. in rats.

Therefore, search for natural active and better alternative for the treatment of peptic ulcer with fewer side effects is an emergency activiyy. Ethanol-induced gastric ulcer According to the method of Cerqueira et al. Stress increases the formation of ROS, decreases the cell proliferation rate, increases gastric juice secretion, and promotes inhibition of prostaglandin synthesis, leading to alterations in the circulating nitric oxide and the gastric mucosa The extract effectively inhibited formation of gastric lesions induced by ethanol.

A new approach to practical acute toxicity testing. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P Animals The study was conducted on Swiss mice of either sex, weighing 25—30 antuulcer. The general signs of toxicity i. Licorice, the roots and stolons of Glycyrrhiza species is one of the oldest medicinal plants used for treatment of peptic ulcer 2.

The aim of present study was to determine the anti ulcer activity of polyherbal formulation including Aloe vera and Glycyrrhiza glabra against aspirin and ethanol induced gastric ulceration in Swiss albino rats. Currently, effective drugs exist for peptic ulcer diseases.